Best of 2014: The 12 vape pens we loved the most this year, reviewed The Denver Post If you vape, you inhale a lot of harmful substances. These can damage your heart and lungs. Have you ever heard reports about this before?, Some confiscated or illicit vape cartridges have tested positive for fentanyl or fentanyl related compounds. Reports from toxicology and law enforcement Is vaping safer than smoking? A pulmonologist weighs in.