Marijuana and Your Lungs: Is Vaping Safe for People with COPD? Smoking and vaping are often compared, but neither is harmless. While they work differently, both can expose the lungs to addictive nicotine and harmful chemicals that impact breathing and overall health. Smoking How Smoking vs Vaping Affects Your Lungs You Must See This ! ! If you vape, you inhale a lot of harmful substances. These can damage your heart and lungs.