Frontiers Glucose 6 Phosphate Dehydrogenase Deficiency and Neonatal Hyperbilirubinemia: Insights on Pathophysiology, Diagnosis, and Gene Variants in Disease Heterogeneity G6PD Deficiency Glucose 6 phosphate dehydrogenase deficiency X linked recessive disorder Leads to low NADPH, impairing glutathione regeneration RBCs are vulnerable to oxidative damage Pathophysiology: In G6PD deficiency: No Understanding and Managing Glucose 6 Phosphate Dehydrogenase Deficiency ScienceDirect Glucose 6 phosphate dehydrogenase (G6PD): Response of the human erythrocyte and another cells to the decrease in their activity